Der Soundtrack zu Serenity wurde von David Newman komponiert und im Oktober 2005 von Varese Sarabande Records veröffentlicht. Er umfasst insgesamt 23 Titel.
Inhalt
| Nummer | Name | Länge |
|---|---|---|
| 1 | Into the River | 3:10 |
| 2 | Escape | 1:30 |
| 3 | Serenity | 0:50 |
| 4 | Going for a Ride | 2:24 |
| 5 | Trading Station Robbery | 3:07 |
| 6 | River goes wild | 1:28 |
| 7 | River and Simon in Locker | 0:55 |
| 8 | Population Dead | 3:55 |
| 9 | Heaven Destroyed | 0:54 |
| 10 | Sheperd Book's Last Words | 1:00 |
| 11 | You're not a Reaver | 0:56 |
| 12 | Mal Decides | 3:09 |
| 13 | Truth/Mal's Speech | 3:36 |
| 14 | Space Battle | 3:21 |
| 15 | Crash Landing | 1:59 |
| 16 | Run to Black | 2:55 |
| 17 | Generator Room | 3:06 |
| 18 | Mal and Op Fight | 2:11 |
| 19 | Jayne and Zoë/Final Battle | 2:44 |
| 20 | Funeral/Rebuilding Serenity | 2:19 |
| 21 | Prep for Flight | 1:33 |
| 22 | Love | 1:06 |
| 23 | End Credits | 1:38 |